Nitrogen recycling buffers against ammonia toxicity from skeletal muscle breakdown in hibernating arctic ground squirrels

Hibernation is a state of extraordinary metabolic plasticity. The pathways of amino acid metabolism as they relate to nitrogen homeostasis in hibernating mammals in vivo is unknown. Here we show, using pulse isotopic tracing, evidence of increased myofibrillar (skeletal muscle) protein breakdown and...

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Udgivet i:Nat Metab
Main Authors: Rice, Sarah A., ten Have, Gabriella A.M., Reisz, Julie A., Gehrke, Sarah, Stefanoni, Davide, Frare, Carla, Barati, Zeinab, Coker, Robert H., D’Alessandro, Angelo, Deutz, Nicolaas E.P., Drew, Kelly L.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744440/
https://ncbi.nlm.nih.gov/pubmed/33288952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-020-00312-4
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