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Advances in microphysiological blood-brain barrier (BBB) models towards drug delivery

Though the blood-brain barrier (BBB) is vital for the maintenance of brain homeostasis, it also accounts for a high attrition rate of therapies targeting the central nervous system (CNS). The challenge of delivery across the BBB is attributed to a combination of low permeability through an endotheli...

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Detalhes bibliográficos
Publicado no:Curr Opin Biotechnol
Main Authors: Lee, Caleb S, Leong, Kam W
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744339/
https://ncbi.nlm.nih.gov/pubmed/32711361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.copbio.2020.06.009
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