Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device – the SERCA-LVAD TRIAL

The SERCA-LVAD trial was a phase 2a trial assessing the safety and feasibility of delivering an adeno-associated vector 1 carrying the cardiac isoform of the sarcoplasmic reticulum calcium ATPase (AAV1/SERCA2a) to adult chronic heart failure patients implanted with a left ventricular assist device....

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Udgivet i:Gene Ther
Main Authors: Lyon, A. R., Babalis, D., Morley-Smith, A. C., Hedger, M., Suarez Barrientos, A., Foldes, G., Couch, L. S., Chowdhury, R. A., Tzortzis, K. N., Peters, N. S., Rog-Zielinska, E. A., Yang, H-Y, Welch, S., Bowles, C. T., Rahman Haley, S., Bell, A. R., Rice, A., Sasikaran, T., Johnson, N. A., Falaschetti, E., Parameshwar, J., Lewis, C., Tsui, S., Simon, A., Pepper, J., Rudy, J. J., Zsebo, K. M., Macleod, K. T., Terracciano, C. M., Hajjar, R. J., Banner, N., Harding, S. E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744277/
https://ncbi.nlm.nih.gov/pubmed/32669717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-020-0171-7
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