Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders

Severe stress exposure causes the loss of dendritic spines on cortical pyramidal neurons and induces psychiatric-like symptoms in rodent models. These effects are strongest following early-life stress and are most persistent on apical dendrites. However, the long-term impacts and temporal effects of...

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Detalhes bibliográficos
Publicado no:Neurobiol Stress
Main Authors: Kaul, Dominic, Smith, Caine C., Stevens, Julia, Fröhlich, Anna S., Binder, Elisabeth B., Mechawar, Naguib, Schwab, Sibylle G., Matosin, Natalie
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7739192/
https://ncbi.nlm.nih.gov/pubmed/33344723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ynstr.2020.100270
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