ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway

Rationale: Vascular microcalcification increases the risk of rupture of vulnerable atherosclerotic lesions. Inhibition of ERK1/2 reduces atherosclerosis in animal models while its role in vascular calcification and the underlying mechanisms remains incompletely understood. Methods: Levels of activat...

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Udgivet i:Theranostics
Main Authors: Zeng, Peng, Yang, Jie, Liu, Lipei, Yang, Xiaoxiao, Yao, Zhi, Ma, Chuanrui, Zhu, Haibo, Su, Jiamin, Zhao, Qian, Feng, Ke, Yang, Shu, Zhu, Yan, Li, Xiaoju, Wang, Wenguang, Duan, Yajun, Han, Jihong, Chen, Yuanli
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2021
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738895/
https://ncbi.nlm.nih.gov/pubmed/33391525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.49771
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