LRP1B or TP53 mutations are associated with higher tumor mutational burden and worse survival in hepatocellular carcinoma

Background: Hepatocellular carcinoma (HCC) is one of the most leading causes of cancer-related mortality worldwide. Immune checkpoint inhibitors (ICIs) have been proved to be beneficial for advanced HCC. Tumor mutational burden (TMB) is an important predictor for efficacy of ICIs. However, the genet...

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Bibliografiske detaljer
Udgivet i:J Cancer
Main Authors: Wang, Longrong, Yan, Kai, He, Xigan, Zhu, Hongxu, Song, Jia, Chen, Shiqing, Cai, Shangli, Zhao, Yiming, Wang, Lu
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2021
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738815/
https://ncbi.nlm.nih.gov/pubmed/33391418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.48983
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