Immunohistochemistry for CCR4 C‐terminus predicts CCR4 mutations and mogamulizumab efficacy in adult T‐cell leukemia/lymphoma

Mogamulizumab targets extracellular N‐terminal domain of CCR4, which is expressed in most adult T‐cell leukemia/lymphoma (ATL) cases. Recently, we reported that CCR4 C‐terminal gain‐of‐function mutations were frequent in ATL cases, and a subgroup with these mutations who were treated without allogen...

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Bibliografiske detaljer
Udgivet i:J Pathol Clin Res
Main Authors: Fujii, Keiichiro, Sakamoto, Yuma, Masaki, Ayako, Murase, Takayuki, Tashiro, Yukie, Yonekura, Kentaro, Utsunomiya, Atae, Ito, Asahi, Kusumoto, Shigeru, Iida, Shinsuke, Ueda, Ryuzo, Ishida, Takashi, Inagaki, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Inc. 2020
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737778/
https://ncbi.nlm.nih.gov/pubmed/33022137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cjp2.180
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