Probing substrate binding to Metallo-β-Lactamase L1 from Stenotrophomonas maltophilia by using site-directed mutagenesis

BACKGROUND: The metallo-β-lactamases are Zn(II)-containing enzymes that hydrolyze the β-lactam bond in penicillins, cephalosporins, and carbapenems and are involved in bacterial antibiotic resistance. There are at least 20 distinct organisms that produce a metallo-β-lactamase, and these enzymes have...

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發表在:	BMC Biochem
Principais autores:	Carenbauer, Anne L, Garrity, James D, Periyannan, Gopal, Yates, Robert B, Crowder, Michael W
格式:	Artigo
語言:	Inglês
出版:	BMC 2002
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC77373/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11876827/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1471-2091-3-4
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