Hemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity

Most cancer cells primarily produce their energy through a high rate of glycolysis followed by lactic acid fermentation even in the presence of abundant oxygen. Pyruvate dehydrogenase kinase (PDK) 1, an enzyme responsible for aerobic glycolysis via phosphorylating and inactivating pyruvate dehydroge...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jin, Ling, Kim, Eun-Yeong, Chung, Tae-Wook, Han, Chang Woo, Park, So Young, Han, Jung Ho, Bae, Sung-Jin, Lee, Jong Rok, Kim, Young Woo, Jang, Se Bok, Ha, Ki-Tae
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736850/
https://ncbi.nlm.nih.gov/pubmed/33318678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79019-1
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