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Metastatic Pancreatic Neuroendocrine Tumors Have Decreased Somatostatin Expression and Increased Akt Signaling

BACKGROUND: Patients with pancreatic neuroendocrine tumors (PNETs) often present with metastases, which reduce survival. Molecular features associated with PNET tumorigenesis have been reported, but mechanisms of metastasis remain incompletely understood. METHODS: RNA sequencing was performed on pri...

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Detalhes bibliográficos
Publicado no:Surgery
Main Authors: Tran, Catherine G., Scott, Aaron T., Li, Guiying, Sherman, Scott K., Ear, Po Hien, Howe, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736292/
https://ncbi.nlm.nih.gov/pubmed/32611516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2020.04.034
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