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CRISPR/Cas Systems to Overcome Challenges in Developing the Next Generation of T Cells for Cancer Therapy
Genetically engineered immune cells with chimeric antigen receptors (CAR) or modified T cell receptors (TCR) have demonstrated their potential as a potent class of new cancer therapeutic strategy. Despite the clinical success of autologous CD19 CAR T cells in hematological malignancies, allogeneic T...
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| Veröffentlicht in: | Adv Drug Deliv Rev |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7736063/ https://ncbi.nlm.nih.gov/pubmed/32707148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2020.07.015 |
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