BRCA1 Promoter Methylation and Clinical Outcomes in Ovarian Cancer: An Individual Patient Data Meta-Analysis

BACKGROUND: BRCA1 methylation has been associated with homologous recombination deficiency, a biomarker of platinum sensitivity. Studies evaluating BRCA1-methylated tubal and ovarian cancer (OC) do not consistently support improved survival following platinum chemotherapy. We examine the characteris...

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Detalhes bibliográficos
Publicado no:J Natl Cancer Inst
Main Authors: Kalachand, Roshni D, Stordal, Britta, Madden, Stephen, Chandler, Benjamin, Cunningham, Julie, Goode, Ellen L, Ruscito, Ilary, Braicu, Elena I, Sehouli, Jalid, Ignatov, Atanas, Yu, Herbert, Katsaros, Dionyssios, Mills, Gordon B, Lu, Karen H, Carey, Mark S, Timms, Kirsten M, Kupryjanczyk, Jolanta, Rzepecka, Iwona K, Podgorska, Agnieszka, McAlpine, Jessica N, Swisher, Elizabeth M, Bernards, Sarah S, O’Riain, Ciaran, O’Toole, Sharon, O’Leary, John J, Bowtell, David D, Thomas, David M, Prieske, Katharina, Joosse, Simon A, Woelber, Linn, Chaudhry, Parvesh, Häfner, Norman, Runnebaum, Ingo B, Hennessy, Bryan T
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735770/
https://ncbi.nlm.nih.gov/pubmed/32413141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djaa070
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