Donor IFNL4 genotype predicts non-relapse mortality after unrelated donor myeloablative hematopoietic cell transplantation for acute leukemia: A retrospective cohort study

BACKGROUND. IFNL4 genotype regulates the immune response by controlling the production of IFN-λ4, a type III interferon. We hypothesized that IFN-λ4 may play a role in infection clearance or alloreactivity in patients with acute leukemia who received myeloablative 10/10 HLA-matched hematopoietic cel...

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Udgivet i:Lancet Haematol
Main Authors: Gadalla, Shahinaz M., Wang, Youjin, Wang, Tao, Onabajo, Olusegun O., Banday, A. Rouf, Obajemu, Adeola, Karaesman, Ezgi, Sucheston-Campbell, Lara, Hahn, Theresa, Sees, Jennifer A., Spellman, Stephen R., Lee, Stephanie J., Katki, Hormuzd A., Prokunina-Olsson, Ludmila
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735535/
https://ncbi.nlm.nih.gov/pubmed/32976751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2352-3026(20)30294-5
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