Evaluation of a novel immunoassay to detect p-tau Thr217 in the CSF to distinguish Alzheimer disease from other dementias

OBJECTIVE: To investigate whether tau phosphorylated at Thr217 (p-tau T217) assay in CSF can distinguish patients with Alzheimer disease (AD) from patients with other dementias and healthy controls. METHODS: We developed and validated a novel Simoa immunoassay to detect p-tau T217 in CSF. There was...

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Publicat a:Neurology
Autors principals: Hanes, Jozef, Kovac, Andrej, Kvartsberg, Hlin, Kontsekova, Eva, Fialova, Lubica, Katina, Stanislav, Kovacech, Branislav, Stevens, Eva, Hort, Jakub, Vyhnalek, Martin, Boonkamp, Lynn, Novak, Michal, Zetterberg, Henrik, Hansson, Oskar, Scheltens, Philip, Blennow, Kaj, Teunissen, Charlotte E., Zilka, Norbert
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734919/
https://ncbi.nlm.nih.gov/pubmed/32973122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000010814
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