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Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive Staphylococcus aureus

[Image: see text] In recent years, novel bacterial topoisomerase inhibitors (NBTIs) have been developed as future antibacterials for treating multidrug-resistant bacterial infections. A series of dioxane-linked NBTIs with an amide moiety has been synthesized and evaluated. Compound 3 inhibits DNA gy...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:ACS Med Chem Lett
Κύριοι συγγραφείς: Lu, Yanran, Papa, Jonathan L., Nolan, Sheri, English, Anthony, Seffernick, Justin T., Shkolnikov, Nicholas, Powell, Josh, Lindert, Steffen, Wozniak, Daniel J., Yalowich, Jack, Mitton-Fry, Mark J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2020
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734797/
https://ncbi.nlm.nih.gov/pubmed/33335666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00428
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