Pharmacological Programming of Endosomal Signaling Activated by Small Molecule Ligands of the Follicle Stimulating Hormone Receptor

Follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor (GPCR) with pivotal roles in reproduction. One key mechanism dictating the signal activity of GPCRs is membrane trafficking. After binding its hormone FSH, FSHR undergoes internalization to very early endosomes (VEEs) for i...

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Udgivet i:Front Pharmacol
Main Authors: Sposini, Silvia, De Pascali, Francesco, Richardson, Rachel, Sayers, Niamh S., Perrais, David, Yu, Henry N., Palmer, Stephen, Nataraja, Selva, Reiter, Eric, Hanyaloglu, Aylin C.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734412/
https://ncbi.nlm.nih.gov/pubmed/33329002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.593492
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