Pharmacological Programming of Endosomal Signaling Activated by Small Molecule Ligands of the Follicle Stimulating Hormone Receptor

Follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor (GPCR) with pivotal roles in reproduction. One key mechanism dictating the signal activity of GPCRs is membrane trafficking. After binding its hormone FSH, FSHR undergoes internalization to very early endosomes (VEEs) for i...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Sposini, Silvia, De Pascali, Francesco, Richardson, Rachel, Sayers, Niamh S., Perrais, David, Yu, Henry N., Palmer, Stephen, Nataraja, Selva, Reiter, Eric, Hanyaloglu, Aylin C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734412/
https://ncbi.nlm.nih.gov/pubmed/33329002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.593492
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