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Production of Noncapped Genomic RNAs Is Critical to Sindbis Virus Disease and Pathogenicity

Alphaviruses are positive-sense RNA viruses that utilize a 5′ cap structure to facilitate translation of viral proteins and to protect the viral RNA genome. Nonetheless, significant quantities of viral genomic RNAs that lack a canonical 5′ cap structure are produced during alphaviral replication and...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: LaPointe, Autumn T., Landers, V Douglas, Westcott, Claire E., Sokoloski, Kevin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733944/
https://ncbi.nlm.nih.gov/pubmed/33262258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02675-20
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