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Decreased mechanotransduction prevents nuclear collapse in a Caenorhabditis elegans laminopathy

The function of the nucleus depends on the integrity of the nuclear lamina, an intermediate filament network associated with the linker of nucleoskeleton and cytoskeleton (LINC) complex. The LINC complex spans the nuclear envelope and mediates nuclear mechanotransduction, the process by which mechan...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Huelgas-Morales, Gabriela, Sanders, Mark, Mekonnen, Gemechu, Tsukamoto, Tatsuya, Greenstein, David
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733798/
https://ncbi.nlm.nih.gov/pubmed/33229589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015050117
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