Targeted photodynamic therapy selectively kills activated fibroblasts in experimental arthritis

OBJECTIVE: In RA, synovial fibroblasts become activated. These cells express fibroblast activation protein (FAP) and contribute to the pathogenesis by producing cytokines, chemokines and proteases. Selective depletion in inflamed joints could therefore constitute a viable treatment option. To this e...

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Detalhes bibliográficos
Publicado no:Rheumatology (Oxford)
Main Authors: Dorst, Daphne N, Rijpkema, Mark, Boss, Marti, Walgreen, Birgitte, Helsen, Monique M A, Bos, Desirée L, Brom, Maarten, Klein, Christian, Laverman, Peter, van der Kraan, Peter M, Gotthardt, Martin, Koenders, Marije I, Buitinga, Mijke
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic and Translational Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733717/
https://ncbi.nlm.nih.gov/pubmed/32734285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keaa295
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