Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells

Anti-PD1 immunotherapy, as a single agent or in combination with standard chemotherapies, has significantly improved the outcome of many patients with cancers. However, resistance to anti-PD1 antibodies often decreases the long-term therapeutic benefits. Despite this observation in clinical practice...

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Vydáno v:Cell Death Dis
Hlavní autoři: Guyon, Nina, Garnier, Delphine, Briand, Joséphine, Nadaradjane, Arulraj, Bougras-Cartron, Gwenola, Raimbourg, Judith, Campone, Mario, Heymann, Dominique, Vallette, François M., Frenel, Jean-Sébastien, Cartron, Pierre-François
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733505/
https://ncbi.nlm.nih.gov/pubmed/33311449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03224-z
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