Mobilization of pre-existing polyclonal T cells specific to neoantigens but not self-antigens during treatment of a patient with melanoma with bempegaldesleukin and nivolumab

T cells that recognize self-antigens and mutated neoantigens are thought to mediate antitumor activity of immune checkpoint blockade (ICB) in melanoma. Few studies have analyzed self and neoantigen-specific T cell responses in patients responding to ICB. Here, we report a patient with metastatic mel...

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Bibliografiske detaljer
Udgivet i:J Immunother Cancer
Main Authors: Veatch, Joshua R, Singhi, Naina, Jesernig, Brenda, Paulson, Kelly G, Zalevsky, Jonathan, Iacucci, Ernesto, Tykodi, Scott S, Riddell, Stanley R
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2020
Fag:
Clinical/Translational Cancer Immunotherapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733177/
https://ncbi.nlm.nih.gov/pubmed/33298619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001591
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