Long-term exposure of human endothelial cells to metformin modulates miRNAs and isomiRs

Increasing evidence suggest that the glucose-lowering drug metformin exerts a valuable anti-senescence role. The ability of metformin to affect the biogenesis of selected microRNAs (miRNAs) was recently suggested. MicroRNA isoforms (isomiRs) are distinct variations of miRNA sequences, harboring addi...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Giuliani, Angelica, Londin, Eric, Ferracin, Manuela, Mensà, Emanuela, Prattichizzo, Francesco, Ramini, Deborah, Marcheselli, Fiorella, Recchioni, Rina, Rippo, Maria Rita, Bonafè, Massimiliano, Rigoutsos, Isidore, Olivieri, Fabiola, Sabbatinelli, Jacopo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732983/
https://ncbi.nlm.nih.gov/pubmed/33311640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78871-5
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