Mitochondrial DNA Affects the Expression of Nuclear Genes Involved in Immune and Stress Responses in a Breast Cancer Model

Tumor cells without mitochondrial (mt) DNA (ρ(0) cells) are auxotrophic for uridine, and their growth is supported by pyruvate. While ATP synthesis in ρ(0) cells relies on glycolysis, they fail to form tumors unless they acquire mitochondria from stromal cells. Mitochondrial acquisition restores res...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Grasso, Carole, Eccles, David A., Boukalova, Stepana, Fabre, Marie-Sophie, Dawson, Rebecca H., Neuzil, Jiri, Herst, Patries M., Berridge, Michael V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732479/
https://ncbi.nlm.nih.gov/pubmed/33329014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.543962
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