Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma

Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major cell clusters are identified based on unbiased clustering of gene expression profiles and can...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Zhou, Yan, Yang, Dong, Yang, Qingcheng, Lv, Xiaobin, Huang, Wentao, Zhou, Zhenhua, Wang, Yaling, Zhang, Zhichang, Yuan, Ting, Ding, Xiaomin, Tang, Lina, Zhang, Jianjun, Yin, Junyi, Huang, Yujing, Yu, Wenxi, Wang, Yonggang, Zhou, Chenliang, Su, Yang, He, Aina, Sun, Yuanjue, Shen, Zan, Qian, Binzhi, Meng, Wei, Fei, Jia, Yao, Yang, Pan, Xinghua, Chen, Peizhan, Hu, Haiyan
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730477/
https://ncbi.nlm.nih.gov/pubmed/33303760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20059-6
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