Acetaminophen-Induced Rat Hepatotoxicity Based on M1/M2-Macrophage Polarization, in Possible Relation to Damage-Associated Molecular Patterns and Autophagy

Overdose of acetaminophen (APAP), an antipyretic drug, is an important cause of liver injury. However, the mechanism in the rat model remains undetermined. We analyzed APAP-induced hepatotoxicity using rats based on M1/M2-macrophage functions in relation to damage-associated molecular patterns (DAMP...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Tsuji, Yuka, Kuramochi, Mizuki, Golbar, Hossain M., Izawa, Takeshi, Kuwamura, Mitsuru, Yamate, Jyoji
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730394/
https://ncbi.nlm.nih.gov/pubmed/33256230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21238998
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