A Variant in the Nicotinic Acetylcholine Receptor Alpha 3 Subunit Gene Is Associated With Hypertension Risks in Hypogonadic Patients

Ephb6 gene knockout causes hypertension in castrated mice. EPHB6 controls catecholamine secretion by adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent way. Nicotinic acetylcholine receptor (nAChR) is a ligand-gated Ca(2+)/Na(+) channel, and its opening is the first signaling event l...

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Vydáno v:Front Genet
Hlavní autoři: Wu, Tao, Wang, Yujia, Shi, Wei, Zhang, Bi-Qi, Raelson, John, Yao, Yu-Mei, Wu, Huan-Dong, Xu, Zao-Xian, Marois-Blanchet, Francois-Christophe, Ledoux, Jonathan, Blunck, Rikard, Sheng, Jian-Zhong, Hu, Shen-Jiang, Luo, Hongyu, Wu, Jiangping
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728919/
https://ncbi.nlm.nih.gov/pubmed/33329690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.539862
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