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(R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages

Cystic fibrosis (CF) is characterized by chronic bacterial infections and heightened inflammation. Widespread ineffective antibiotic use has led to increased isolation of drug resistant bacterial strains from respiratory samples. (R)-roscovitine (Seliciclib) is a unique drug that has many benefits i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Shrestha, Chandra L., Zhang, Shuzhong, Wisniewski, Benjamin, Häfner, Stephanie, Elie, Jonathan, Meijer, Laurent, Kopp, Benjamin T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728753/
https://ncbi.nlm.nih.gov/pubmed/33303916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78817-x
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