Xeroderma Pigmentosum C (XPC) Mutations in Primary Fibroblasts Impair Base Excision Repair Pathway and Increase Oxidative DNA Damage

Xeroderma Pigmentosum C (XPC) is a multi-functional protein that is involved not only in the repair of bulky lesions, post-irradiation, via nucleotide excision repair (NER) per se but also in oxidative DNA damage mending. Since base excision repair (BER) is the primary regulator of oxidative DNA dam...

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Bibliographic Details
Published in:Front Genet
Main Authors: Fayyad, Nour, Kobaisi, Farah, Beal, David, Mahfouf, Walid, Ged, Cécile, Morice-Picard, Fanny, Fayyad-Kazan, Mohammad, Fayyad-Kazan, Hussein, Badran, Bassam, Rezvani, Hamid R., Rachidi, Walid
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728722/
https://ncbi.nlm.nih.gov/pubmed/33329698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.561687
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