Reduction of free polysaccharide contamination in the production of a 15-valent pneumococcal conjugate vaccine

Glycoconjugate vaccines are vaccines in which a bacterial polysaccharide antigen is conjugated to a carrier protein to enhance immunogenicity by promoting T cell-dependent immune response. However, the free (unreacted) polysaccharides remaining after the conjugation process can inhibit the immunogen...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Whang, Yoon Hee, Kim, Soo Kyung, Yoon, Hyeseon, Choi, Seuk Keun, Baik, Yeong Ok, Lee, Chankyu, Lee, Inhwan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728214/
https://ncbi.nlm.nih.gov/pubmed/33301525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0243909
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