COX-2 Is Downregulated in Human Stenotic Aortic Valves and Its Inhibition Promotes Dystrophic Calcification

Calcific aortic valve disease (CAVD) is the result of maladaptive fibrocalcific processes leading to a progressive thickening and stiffening of aortic valve (AV) leaflets. CAVD is the most common cause of aortic stenosis (AS). At present, there is no effective pharmacotherapy in reducing CAVD progre...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Vieceli Dalla Sega, Francesco, Fortini, Francesca, Cimaglia, Paolo, Marracino, Luisa, Tonet, Elisabetta, Antonucci, Antonio, Moscarelli, Marco, Campo, Gianluca, Rizzo, Paola, Ferrari, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7727817/
https://ncbi.nlm.nih.gov/pubmed/33255450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21238917
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