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Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains

Amyloid precursor protein (APP) at the plasma membrane is internalized via endocytosis and delivered to endo/lysosomes, where neurotoxic amyloid-β (Aβ) is produced via β-, γ-secretases. Hence, endocytosis plays a key role in the processing of APP and subsequent Aβ generation. β-, γ-secretases as wel...

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Vydáno v:Molecules
Hlavní autoři: Cho, Yoon Young, Kwon, Oh-Hoon, Chung, Sungkwon
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7727664/
https://ncbi.nlm.nih.gov/pubmed/33255194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25235490
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