Dysregulation of Endothelial Nitric Oxide Synthase Does Not Depend on Hemodynamic Alterations in Bicuspid Aortic Valve Aortopathy

BACKGROUND: Bicuspid aortic valves (BAVs) predispose to ascending aortic aneurysm. Turbulent blood flow and genetic factors have been proposed as underlying mechanisms. Endothelial nitric oxide synthase (eNOS) has been implicated in BAV aortopathy, and its expression is regulated by wall shear stres...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Gauer, Simon, Balint, Brittany, Kollmann, Catherine, Federspiel, Jan M., Henn, Dominic, Bandner‐Risch, Doris, Schmied, Wolfram, Schäfers, Hans‐Joachim
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726972/
https://ncbi.nlm.nih.gov/pubmed/32873108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.120.016471
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