Terpene Chain Length Affects the Base Pairing Discrimination of S-geranyl-2-thiouridine in RNA Duplex

Geranylation is a hydrophobic modification discovered in several bacteria tRNAs with the function of promoting codon bias during translation. However, why nature selects this C10-geranyl group remains a question. We conduct synthesis, UV-thermal denaturation, and molecular simulation studies in RNA...

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Vydáno v:iScience
Hlavní autoři: Haruehanroengra, Phensinee, Vangaveti, Sweta, Ranganathan, Srivathsan V., Mao, Song, Su, Max Daniel, Chen, Alan A., Sheng, Jia
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726334/
https://ncbi.nlm.nih.gov/pubmed/33319183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101866
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