Whole-Brain Three-Dimensional Profiling Reveals Brain Region Specific Axon Vulnerability in 5xFAD Mouse Model

Axonopathy is a pathological feature observed in both Alzheimer’s disease (AD) patients and animal models. However, identifying the temporal and regional progression of axonopathy during AD development remains elusive. Using the fluorescence micro-optical sectioning tomography system, we acquired wh...

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Udgivet i:Front Neuroanat
Main Authors: Zhang, Jianping, Long, Ben, Li, Anan, Sun, Qingtao, Tian, Jiaojiao, Luo, Ting, Ding, Zhangheng, Gong, Hui, Li, Xiangning
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Neuroanatomy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726261/
https://ncbi.nlm.nih.gov/pubmed/33324177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnana.2020.608177
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