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Application of the PET ligand [(11)C]ORM-13070 to examine receptor occupancy by the α(2C)-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain
BACKGROUND: Availability of the α(2C)-adrenoceptor (α(2C)-AR) positron emission tomography (PET) tracer, [(11)C]ORM-13070, and the α(2C)-AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor subtype in brain function, both in healthy humans and in patients with vario...
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| Опубликовано в: : | EJNMMI Res |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Springer Berlin Heidelberg
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7726058/ https://ncbi.nlm.nih.gov/pubmed/33296042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-020-00741-y |
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