Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster

Degradation of polychlorinated biphenyls (PCBs) is initiated by cytochrome P450 (CYP) enzymes and includes PCB oxidation to OH-metabolites, which often display a higher toxicity than their parental compounds. In search of an animal model reflecting PCB metabolism and toxicity, we tested Drosophila m...

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Pubblicato in:Sci Rep
Autori principali: Idda, T., Bonas, C., Hoffmann, J., Bertram, J., Quinete, N., Schettgen, T., Fietkau, K., Esser, A., Stope, M. B., Leijs, M. M., Baron, J. M., Kraus, T., Voigt, A., Ziegler, P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726022/
https://ncbi.nlm.nih.gov/pubmed/33299007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78405-z
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