Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration

Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk associated with polymorphisms in the complement fa...

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Udgivet i:Front Pharmacol
Main Authors: Stravalaci, Matteo, Davi, Francesca, Parente, Raffaella, Gobbi, Marco, Bottazzi, Barbara, Mantovani, Alberto, Day, Anthony J., Clark, Simon J., Romano, Mario R., Inforzato, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725797/
https://ncbi.nlm.nih.gov/pubmed/33324220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.591908
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