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Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans

Transgenes are prone to progressive silencing due to their structure, copy number, and genomic location. In C. elegans, repressive mechanisms are particularly strong in the germline with almost fully penetrant transgene silencing in simple extrachromosomal arrays and frequent silencing of single-cop...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Aljohani, Mohammed D., El Mouridi, Sonia, Priyadarshini, Monika, Vargas-Velazquez, Amhed M., Frøkjær-Jensen, Christian
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725773/
https://ncbi.nlm.nih.gov/pubmed/33298957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19898-0
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