Digital-WGS: Automated, highly efficient whole-genome sequencing of single cells by digital microfluidics

Single-cell whole-genome sequencing (WGS) is critical for characterizing dynamic intercellular changes in DNA. Current sample preparation technologies for single-cell WGS are complex, expensive, and suffer from high amplification bias and errors. Here, we describe Digital-WGS, a sample preparation p...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Ruan, Qingyu, Ruan, Weidong, Lin, Xiaoye, Wang, Yang, Zou, Fenxiang, Zhou, Leiji, Zhu, Zhi, Yang, Chaoyong
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725457/
https://ncbi.nlm.nih.gov/pubmed/33298451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd6454
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