A pH-Responsive Silica–Metal–Organic Framework Hybrid Nanoparticle for the Delivery of Hydrophilic Drugs, Nucleic Acids, and CRISPR-Cas9 Genome-Editing Machineries

Efficient delivery of hydrophilic drugs, nucleic acids, proteins, and any combination thereof is essential for various biomedical applications. Herein, we report a straightforward, yet versatile approach to efficiently encapsulate and deliver various hydrophilic payloads using a pH-responsive silica...

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Pubblicato in:J Control Release
Autori principali: Wang, Yuyuan, Shahi, Pawan K., Xie, Ruosen, Zhang, Huilong, Abdeen, Amr A., Yodsanit, Nisakorn, Ma, Zhenqiang, Saha, Krishanu, Pattnaik, Bikash, Gong, Shaoqin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725380/
https://ncbi.nlm.nih.gov/pubmed/32380204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.04.052
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