SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

Coronavirus disease 2019 (COVID-19) includes the cardiovascular complications in addition to respiratory disease. SARS-CoV-2 infection impairs endothelial function and induces vascular inflammation, leading to endotheliitis. SARS-CoV-2 infection relies on the binding of Spike glycoprotein (S protein...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Lei, Yuyang, Zhang, Jiao, Schiavon, Cara R., He, Ming, Chen, Lili, Shen, Hui, Zhang, Yichi, Yin, Qian, Cho, Yoshitake, Andrade, Leonardo, Shadel, Gerry S., Hepokoski, Mark, Lei, Ting, Wang, Hongliang, Zhang, Jin, Yuan, Jason X.-J., Malhotra, Atul, Manor, Uri, Wang, Shengpeng, Yuan, Zu-Yi, Shyy, John Y-J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7724674/
https://ncbi.nlm.nih.gov/pubmed/33300001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.04.409144
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