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A single intranasal or intramuscular immunization with chimpanzee adenovirus vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters

The development of an effective vaccine against SARS-CoV-2, the etiologic agent of COVID-19, is a global priority. Here, we compared the protective capacity of intranasal and intramuscular delivery of a chimpanzee adenovirus-vectored vaccine encoding a pre-fusion stabilized spike protein (ChAd-SARS-...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Bricker, Traci L., Darling, Tamarand L., Hassan, Ahmed O., Harastani, Houda H., Soung, Allison, Jiang, Xiaoping, Dai, Ya-Nan, Zhao, Haiyan, Adams, Lucas J., Holtzman, Michael J., Bailey, Adam L., Case, James Brett, Fremont, Daved H., Klein, Robyn, Diamond, Michael S., Boon, Adrianus C. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7724659/
https://ncbi.nlm.nih.gov/pubmed/33299991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.02.408823
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