Soluble guanylyl cyclase stimulation and phosphodiesterase-5 inhibition improve portal hypertension and reduce liver fibrosis in bile duct–ligated rats

BACKGROUND: In cirrhosis, the nitric oxide-soluble guanylyl cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway is impaired, which contributes to increased intrahepatic vascular resistance (IHVR) and fibrogenesis. We investigated if sGC stimulation (riociguat (RIO)), sGC activation (cinacigu...

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Dades bibliogràfiques
Publicat a:United European Gastroenterol J
Autors principals: Brusilovskaya, Ksenia, Königshofer, Philipp, Lampach, Daniel, Szodl, Adrian, Supper, Paul, Bauer, David, Beer, Andrea, Stift, Judith, Timelthaler, Gerald, Oberhuber, Georg, Podesser, Bruno Karl, Seif, Martha, Zinober, Kerstin, Rohr-Udilova, Nataliya, Trauner, Michael, Reiberger, Thomas, Schwabl, Philipp
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2020
Matèries:
Hepatobiliary
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7724531/
https://ncbi.nlm.nih.gov/pubmed/32878579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2050640620944140
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