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Regulation and Roles of the Nucleolus in Embryonic Stem Cells: From Ribosome Biogenesis to Genome Organization

The nucleolus is the largest compartment of the eukaryotic cell's nucleus. It acts as a ribosome factory, thereby sustaining the translation machinery. The nucleolus is also the subnuclear compartment with the highest transcriptional activity in the cell, where hundreds of ribosomal RNA (rRNA)...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Gupta, Shivani, Santoro, Raffaella
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7724472/
https://ncbi.nlm.nih.gov/pubmed/32976768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.08.012
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