Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells

Insulin is an essential growth factor for the survival and self-renewal of human embryonic stem cells (hESCs). Although it is best known as the principal hormone promoting glycolysis in somatic cells, insulin's roles in hESC energy metabolism remain unclear. In this report, we demonstrate that...

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Udgivet i:Stem Cell Reports
Main Authors: Ren, Zhili, Zhong, Hui, Song, Chengcheng, Deng, Chunhao, Hsieh, Hsun-Ting, Liu, Weiwei, Chen, Guokai
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7724469/
https://ncbi.nlm.nih.gov/pubmed/33186539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.10.008
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