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Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma

PURPOSE: We hypothesized that the combination of a local stimulus for activating tumor-specific T cells and an anti-immunosuppressant would improve treatment of gliomas. Virally encoded IL15Rα-IL15 as the T-cell activating stimulus and a prostaglandin synthesis inhibitor as the anti-immunosuppressan...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Tang, Bingtao, Guo, Zong Sheng, Bartlett, David L., Yan, David Z., Schane, Claire P., Thomas, Diana L., Liu, Jia, McFadden, Grant, Shisler, Joanna L., Roy, Edward J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7723446/
https://ncbi.nlm.nih.gov/pubmed/32019860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3626
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