Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation

VP1, a pivotal capsid protein encoded by the foot-and-mouth disease virus (FMDV), plays an important role in receptor-mediated attachment and humoral immune responses. Previous studies show that amino acid changes in the VP1 protein of cell culture-adapted strains of FMDV alter the properties of the...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Ekanayaka, Pathum, Lee, Seo-Yong, Herath, Thilina U. B., Kim, Jae-Hoon, Kim, Tae-Hwan, Lee, Hyuncheol, Chathuranga, Kiramage, Chathuranga, W. A. Gayan, Park, Jong-Hyeon, Lee, Jong-Soo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7723281/
https://ncbi.nlm.nih.gov/pubmed/33232374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009057
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