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Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)

Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that autoreactive T cells mistakenly destroy healthy (‘innocent’) β-cells. We propose an alternative view in which the...

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Détails bibliographiques
Publié dans:Nat Rev Endocrinol
Auteurs principaux: Roep, Bart O., Thomaidou, Sofia, van Tienhoven, René, Zaldumbide, Arnaud
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722981/
https://ncbi.nlm.nih.gov/pubmed/33293704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41574-020-00443-4
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