Noise Exposures Causing Hearing Loss Generate Proteotoxic Stress and Activate the Proteostasis Network

Exposure to excessive sound causes noise-induced hearing loss through complex mechanisms and represents a common and unmet neurological condition. We investigate how noise insults affect the cochlea with proteomics and functional assays. Quantitative proteomics reveals that exposure to loud noise ca...

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Publicado en:Cell Rep
Main Authors: Jongkamonwiwat, Nopporn, Ramirez, Miguel A., Edassery, Seby, Wong, Ann C.Y., Yu, Jintao, Abbott, Tirzah, Pak, Kwang, Ryan, Allen F., Savas, Jeffrey N.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722268/
https://ncbi.nlm.nih.gov/pubmed/33238128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108431
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